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Effect of Serum Albumin Levels on COVID-19 Mortality
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Saiyad Bastaminejad    , Aliashraf Mozafari , Elham Shafiei , Mohammadreza Kaffashian , Iraj Ahmadi , Yousef Jamshidbeigi * |
| Ilam University of Medical sciences |
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Abstract: (1393 Views) |
Background and Objective: Human serum albumin (HSA) is known as an acute phase reactant with antioxidant properties. Limited studies, to the best of our knowledge, were conducted on the correlation between low serum albumin levels and COVID-19 mortality.
Materials and Methods: The present registry-based, single-center retrospective cohort study was conducted on patients with COVID-19 admitted to the hospital affiliated with Ilam University of Medical Sciences, Iran from March 5, 2020 to March 21, 2021. In this study, Cox regression models are applied to a dataset of 2441 patients with COVID-19.
Results: Patients with lower albumin levels had a higher in-hospital death than those with normal albumin levels (31% vs. 13.5%). The median survival time was 31 days for patients with normal serum albumin and 22 days for those with Hypoalbuminemia. The Cox regression analysis of albumin (adjusted hazard ratio; 0.74, 95% CI: 0.55 – 0.98, p= 0.04) indicated that each additional unit of albumin level increases the survival rate in patients up to 16%.
Conclusion: The present study demonstrated that low albumin levels were associated with the severity of the disease and higher in-hospital mortality in COVID-19 patients. |
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| Keywords: COVID-19, Albumin, survival, Mortality |
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Full-Text [PDF 1345 kb]
(360 Downloads)
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Type of Study: Basic Research |
Subject:
Special
Received: 2022/11/1 | Accepted: 2023/01/4 | Published: 2023/03/21
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