Background and Objective: The lack of attention to drug-nutrient interactions in long-term use or extended hospitalizations can results in malnutrition, treatment failure, side effects, or, in some serious cases, life-threatening events, including death. The present study was designed and carried out to assess the status of nutrient supplementation due to drug-nutrient interactions in patients admitted to the ICU of Imam Khomeini Hospital in Urmia during the first half of 2021. Materials and Methods: In this descriptive, analytical, retrospective study, we examined the records of all patients admitted to ICU departments in an educational hospital during the first half of 2021. Nintey eligible hospitalized patients in the intensive care unit were included. Data on the drugs received, nutritional supplements, hospitalization period, method of drug administration, and demographic information were extracted. To determine drug interactions for each patient, the Nutrient Drug Interaction Guideline published by the Ministry of Health, Medicine and Medical Education and other accessible scientific documents were used. Results: Of the 90 patients studied, 55 patients (61.1%) were male and 35 patients (38.9%) were female. The mean age of the studied patients was 51.09 ± 13.79 years. The most commonly used supplements were calcium carbonate, folic acid, Nephrovit and vitamin C, respectively. The most prevalent identified drug-nutrient interactions were between pantoprazole-folic acid, dexamethasone-calcium carbonate, vitamin B12-pantoprazole, vitamin Kaspirin, and vitamin D-dexamethasone. Conclusion: The results of this study showed a high incidence of drug interactions in these patients, particularly in the realm of drug-nutrient interactions. The most common drugs contributing to drug-nutrient interaction in patients admitted to the intensive care unit are frequently employed hospital medications, including digestive system drugs, corticosteroids, antibiotics, and anticoagulants.